bsm-30307A-PACIFIC BLUE

DATASHEET

Host: Rat

Target Protein: Receptor-type tyrosine-protein phosphatase C

Clonality: Monoclonal

Isotype: IgG2a/Kappa

Entrez Gene: 19264

Swiss Prot: P06800

Purification: Affinity purified by Protein G

Storage Buffer: 0.01M PBS, 0.5%BSA, 0.02% Proclin300

Storage: Store at 2-8℃. Protect from light. Avoid freezing.

Background:

CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

Size: 25T,100T

Concentration: n/a

Applications: FCM(10l per million cells in 282l staining volume)

Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.